Closer look at a man's sexuality reveals that, his sexual capabilities are not confined within a constant magnitude. It's a variable that keeps falling and rising. Often men come across an age when they do have developed a sound family, but are rendered sexually incapable due to the tremendous efforts they made in getting at that stage of life. Distractions, emotional traumas, tension, mental stress and lack of sexual motivation are some of the notable causes of such an event. Considering the problem, Pfizer pharmaceuticals in 1998, experimented with a drug that caused vasodilatation in a man's lungs and penile blood vessels. Upon testing it for erectile dysfunction, they found it amazingly effective in alleviating the disease. Expanding the project on industrial scale, they successfully eradicated reduced sexual drive, vigor and lack of motivation in men with the drug they named Viagra. It has become a standard whenever it comes to cure ED or to be used as a luxury in accelerating sexual joy.

The basic mechanism the drug adopts when it enters the blood stream after being absorbed from the intestinal tact as the drug is administered orally is to sequester the action of PDE-5, a cGMP degrader. Why cGMP is required to cause erection and where is it required? The answer to this question lies in the fact that PDE-5 is an enzyme specifically located in penile tissues and is capable of decreasing or down-regulating the erection level by regulating or decreasing the quantity of the blood flow to the spongy organs of the penis, the corpora cavernosa. In an untreated patient of ED, the sexual stimulation is rendered not enough or the mechanism of cGMP production, probably due to decreased NO production, is not effective enough to produce sufficient quantities of cGMP to cause vasodilatation of the penile blood vessels, in other words incapable of increasing the blood vessel diameter enough to provide sufficient quantity of blood to the erection causing organs of the penis. This where the drug comes, it does not increases cGMP production instead it blocks the degradation of it. Eventually, after sufficient sexual stimulation, there accumulates enough cGMP to bring about a successful erection and moreover, to maintain it after it has been achieved.

The drug is designed in the form of orally administered tablets of three potencies, 25 mg, 50 mg and 100 mg. 25 mg tablet half an hour before sexual interaction and for once every 24 hours. 25 mg tablet is preferred as a loading dose, if rendered ineffective for the particular individual, increase the drug dosage after physician's recommendation. Since beta blockers and nitrates mimic the action of the drug, they are highly contraindicated with Viagra. Do not take protease inhibitors and erythromycin antibiotic with the drug. Possible side effects of the drug include cyanotic vision, dizziness, dyspepsia, diarrhea, priapism, hearing loss, flushing and nasal congestion. In case of persistence of any of these symptoms, consult your physician immediately.

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